Decapeptide-12 (200mg) – Research Peptide

Looking for a serious research peptide that targets tyrosinase activity? This is it. Decapeptide-12 is a 12-amino acid sequence (Tyr-Arg-Ser-Aar-Lysd-Tyr-Ser-Ser-Trp-Tyr) designed for laboratory investigation into melanin regulation pathways. The data is compelling, and we stock it for researchers who need reliable, high-purity materials.

Key Research Points

The core proposed mechanism is the inhibition of tyrosinase, the key enzyme in melanin production. Think of it as a potential tool for studying hyperpigmentation models in a controlled setting.

Published studies (see references below) have reported notable observations in research models. For instance, in models of melasma (photodamage), one study noted approximately 40% of subjects achieved a standardized epidermal tone after a 12-week protocol. In separate solar lentigines models, about 38.5% of cases suggested complete clearance after 24 weeks. Another study pointed to a significant reduction in post-inflammatory hyperpigmentation markers compared to controls.

Beyond direct tyrosinase interaction, research suggests Decapeptide-12 may influence cellular metabolism pathways. One in-vitro study reported marked upregulation of SIRT1 (141%), SIRT3 (121%), and SIRT6 (147%) gene transcription in keratinocyte progenitors, pointing to potential roles in oxidative stress response and DNA repair mechanisms worthy of further study.

Specifications & Handling

• Purity: >99%
• Quantity: 200mg
• Sequence: Tyr-Arg-Ser-Aar-Lysd-Tyr-Ser-Ser-Trp-Tyr
• Molecular Formula: C65H90N18O17
• Molecular Weight: 1311.46 g/mol
• CAS Number: 137665-91-9

Note on Lipophilicity: The native peptide has a lyophobic structure. Research indicates modification with a palmitate chain can enhance epidermal penetration in models while maintaining inhibitory activity. Plan your vehicle accordingly.

Bottom Line for Researchers

If your work involves pigmentogenesis, cellular aging, or skin response models, Decapeptide-12 presents a well-documented compound for in-vitro application. The referenced literature provides a solid foundation for experimental design.