Nonapeptide-1 (Melanostatine-5) | 200mg Research Peptide

Price: $240.90 | In Stock. Ships Today if ordered by 12 PM PST.

This is Nonapeptide-1, 200mg of high-purity research material. Also known as Melanostatine-5. The sequence is Met-Pro-D-Phe-Arg-D-Trp-Phe-Lys-Pro-Val. We stock it because the published data on its mechanism is compelling for specific research applications, particularly involving the melanocortin-1 receptor (MC1R).

Here’s what the literature says: In screening studies of over 31,000 compounds, this specific nine-amino-acid structure came out as one of the most potent MC1R antagonists identified. The D-Trp and D-Phe residues are key. The primary research focus is on its potential to inhibit melanin synthesis in melanocytes by blocking the MC1R receptor, disrupting the α-MSH signaling pathway. This has placed it at the center of studies on hyperpigmentation conditions in model systems.

Beyond the basic mechanism, cell studies (using HaCaT and HEM cells) suggest it may downregulate MC1R expression itself and reduce levels of key proteins like tyrosinase, TRP-1, TRP-2, and MITF after UV exposure. This indicates a multi-pathway approach to inhibiting pigment production.

A controlled pilot study on a melasma model noted a consistent reduction in severity scores and melanin index versus a control group. Other research into MC1R inhibition (using similar antagonists) has shown slowed growth and reduced morphological heterogeneity in certain melanoma cell lines, though Nonapeptide-1 specifically requires more study in that context. There is also evidence from related compounds suggesting MC1R antagonism in the central nervous system may modulate inflammatory pain response, though again, direct data with Nonapeptide-1 is needed.

Specifications:

• Purity: >98%
• Sequence: Met-Pro-D-Phe-Arg-D-Trp-Phe-Lys-Pro-Val-NH₂
• Molecular Formula: C61H87N15O9S
• Molecular Weight: 1206.52 g/mol
• Synonyms: Melanostatine-5, Oxytocin Intermediate-nine peptide

Important Notice: This product is for research use only in a controlled laboratory setting. It is a chemical for in-vitro study, not for human or animal consumption. It is not a drug, cosmetic, or supplement. You must be a licensed researcher or qualified professional to purchase. By purchasing, you confirm you understand and agree to these terms and will adhere to all applicable laws.

References: The claims herein are based on the published research cited in the full description (Jayawickreme et al., J Biol Chem, 1994; Boo YC, Biomedicines, 2020; Chatterjee et al., Indian J Dermatol Venereol Leprol, 2021; Kansal et al., Oncotarget, 2016; among others).