Pentapeptide-18 (Leuphasyl) – 200mg

SKU: Research-Grade Synthetic Peptide | Purity: >99%

Price: $236.50

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What You’re Getting

This is 200mg of pure, research-grade Pentapeptide-18, also known in the literature as Leuphasyl. Sequence: Tyr-D-Ala-Gly-Phe-Leu. Molecular Weight: 569.65 g/mol. It’s a modified, stabilized analog of the endogenous peptide Leu-Enkephalin, designed for stability and research efficacy. Think of it as a precision tool for specific in-vitro studies.

The Core Mechanism: Targeted Signal Interference

Here’s the straightforward breakdown. Pentapeptide-18 is studied for its potential to modulate key neurotransmitters at the synaptic level. The primary research indicates it may interfere with the release of acetylcholine, the primary chemical signal that triggers muscle fiber contraction.

By potentially reducing acetylcholine secretion in the synaptic cleft—through a proposed modulation of calcium influx in presynaptic neurons—this peptide is hypothesized to decrease neuromuscular signal strength. Some in-vitro data also notes an observed ~11% reduction in glutamate release, another excitatory neurotransmitter. The bottom line for researchers: it’s a compound of interest for studying the direct inhibition of contraction signals.

Documented Research Outcomes

This isn’t speculation; it’s based on published work. In controlled experimental models, topical application of a 5% Pentapeptide-18 formulation was associated with observable changes.

• Wrinkle Trajectory Reduction: One study reported average reductions of 34.7% in the frontal (inter-brow) zone and 28.4% in the periorbital (eye) zone after a set period.
• Direct Comparative Data: Research by Dr. Howard Maibach’s team found 5% Pentapeptide-18 alone was associated with an approximate 11% reduction in wrinkle depth. Notably, when combined with 5% Argireline (Acetyl Hexapeptide-8), the observed effect increased to an average of ~25% reduction, with maximum values noted around 47%. The mean data was 11.64% (Pentapeptide-18), 16.26% (Argireline), and 24.62% (combination).
• Additional Research Pathway: Modified versions of this peptide, specifically a hexapeptide with D-Tyrosine added, have shown preliminary in-vitro potential to influence melanogenesis in MNT-1 melanoma cells, suggesting a separate research avenue for hyperpigmentation studies.

Why Researchers Choose This Peptide

Compared to paralytic toxins, Pentapeptide-18 represents a synthetic, research-accessible alternative for studying neuromuscular modulation. Its molecular design allows for topical penetration in experimental formulations, making it a subject of interest for dermal research applications. The data on combination use with Argireline suggests a synergistic effect worth investigating further.

Specifications & Handling

• Molecular Formula: C29H39N5O7</li