N-Acetyl Semax (25mg) – Research Grade

Price: $62.70

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Here’s the straight talk on N-Acetyl Semax. Think of it as an upgraded, more resilient version of the classic Semax peptide. The core is the same 4-amino-acid fragment (Met-Glu-His-Phe) found in ACTH. The key difference is the addition of two elements: an acetyl group at the N-terminus and a Pro-Gly-Pro (PGP) tripeptide at the C-terminus.

This isn’t just a minor tweak. The acetylation is believed to shield the peptide from rapid enzymatic breakdown, potentially giving it a longer functional lifespan in research models. The attached PGP fragment is the real point of interest. Research suggests this modification significantly increases the molecule’s lipophilicity—its ability to dissolve in fats. Why does that matter? The blood-brain barrier (BBB) is highly selective, but it’s more permeable to lipid-soluble compounds. The design hypothesis is that this enhanced lipophilicity may improve passive diffusion or facilitate specific transport mechanisms, allowing more of the compound to potentially reach target neural tissues.

Research Context & Potential Applications:

The body of research is built on studies of standard Semax, providing a strong foundation for investigative work with this acetylated analog. Key areas of scientific inquiry include:

• Cognitive Function: Semax research has shown notable impacts on memory formation, recall, and attention in models, with observed increases in brain activation patterns via fMRI.
• Neurotrophic Support: A primary mechanism of interest is the potential upregulation of Brain-Derived Neurotrophic Factor (BDNF). Studies indicate Semax may increase BDNF levels and activate its primary receptor, trkB, in specific brain regions like the hippocampus. This pathway is crucial for neuronal survival, plasticity, and cognitive function.
• Neuroprotection: Research in ischemic models suggests Semax may help modulate key proteins involved in inflammation (like JNK, MMP-9) and cell survival (like CREB), indicating a potential role in supporting neural recovery after injury.
• Systemic Effects: Data points to potential positive effects beyond the CNS. Notably, studies have examined its influence on gastric ulcer healing rates and interactions with neurotransmitter systems like serotonin and enkephalins.

Bottom Line for Researchers:

N-Acetyl Semax is for the serious lab looking at nootropic mechanisms, neuroprotection, or BDNF pathway modulation. The structural modifications aim to solve two key problems: getting more compound across the BBB and keeping it stable longer in the system. The existing Semax data provides a robust map for where this analog might be headed.

Specifications

• Purity: >99% (HPLC verified)
• Molecular Formula: C37H51N9O10S
• Molecular Weight: 858.97 g/mol
• Sequence: Ac-Met-Glu-His-Phe-Pro-Gly-Pro-NH2
• Quantity: 25mg in sterile glass vial</li